Virus-mimicking nano-constructs as a contrast agent for near infrared photoacoustic imaging
نویسندگان
چکیده
منابع مشابه
Virus-mimicking nano-constructs as a contrast agent for near infrared photoacoustic imaging.
We report the first proof-of-principle demonstration of photoacoustic imaging using a contrast agent composed of a plant virus protein shell, which encapsulates indocyanine green (ICG), the only FDA-approved near infrared chromophore. These nano-constructs can provide higher photoacoustic signals than blood in tissue phantoms, and display superior photostability compared to non-encapsulated ICG...
متن کاملNear-infrared absorbing polymer nano-particle as a sensitive contrast agent for photo-acoustic imaging.
Polymer nano-particles (PNPs) with a near-infrared (NIR) light absorption were prepared by the nano-emulsion method to develop contrast agents for photo-acoustic (PA) imaging. The PNP containing silicon naphthalocyanine showed a high absorption coefficient up to 10(10) M(-1) cm(-1). This is comparable to plasmonic gold nano-particles, which have been studied as PA contrast agents. For the PNP l...
متن کاملNear-infrared dye-loaded magnetic nanoparticles as photoacoustic contrast agent for enhanced tumor imaging
Objective: Photoacoustic (PA) tomography (PAT) has attracted extensive interest because of its optical absorption contrast and ultrasonic detection. This study aims to develop a biocompatible and biodegradable PA contrast agent particularly promising for clinical applications in human body. Methods: In this study, we presented a PA contrast agent: 1, 2-distearoyl-sn-glycero-3-phosphoethanolamin...
متن کاملPhotoacoustic Imaging of a Non- Targeted Contrast Agent in Breast- Tissue-Mimicking Phantoms
Our preliminary photoacoustic data indicates that we could detect small objects (tubes with a cross-section of 1mm) containing 100 micro moles of contrast agent up to about 5cm in the breast-tissue like environment. For the case of 10 micro moles concentration of the dye, we could detect such small objects up to about 3cm. This depth can be increased further (by at least another 2cm) by the use...
متن کاملPhotoacoustic contrast imaging of biological tissues with nanodiamonds fabricated for high near-infrared absorbance.
Radiation-damaged nanodiamonds (DNDs) are potentially ideal optical contrast agents for photoacoustic (PA) imaging in biological tissues due to their low toxicity and high optical absorbance. PA imaging contrast agents have been limited to quantum dots and gold particles, since most existing carbon-based nanoparticles, including fluorescent nanodiamonds, do not have sufficient optical absorptio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nanoscale
سال: 2013
ISSN: 2040-3364,2040-3372
DOI: 10.1039/c3nr34124k